技術(shù)參數(shù):
距離:13.3cm
容器數(shù)量:2 x 2
頻率:300rpm
幅度:0-15o可調(diào)
計(jì)時(shí)器(選配):0.01s-99.99min
外型尺寸:55 x 40 x 32cm
附:二甲基硅油(Simethicone)消泡性能美國藥典測(cè)試方法
Defoaming ActivityFoaming solution: 10 mg/mL of octoxynol 9 in water
Sample solution: 4 mg/mL of Simethicone in tertiary butyl alcohol. Shake vigorously.[Note—Warm slightly, if necessary, to dissolve. ]
Analysis
[Note—For each test, use a clean, unused, 250-mL glass jar. ]
Add, dropwise, 500 μL of the Sample solution to a clean, unused, cylindrical 250-mL glass jar, fitted with a 50-mm cap, containing 100 mL of the Foaming solution. Cap the jar, and clamp it in an upright position on a wrist-action shaker. Using a radius of 13.3 ± 0.4 cm (measured from the center of the shaft to the center of the bottle), shake for 10 s through an arc of 10 at a frequency of 300 ± 30 strokes/min. Record the time required for the foam to collapse. The time, in s, for foam collapse is determined at the instant the first portion of foam-free liquid surface appears, measured from the end of the shaking period.
Acceptance criteria: The defoaming activity time does not exceed 15 s.